Please Wait.....
Report
Unresectable Hepatocellular Carcinoma - Market Share Analysis, Industry Trends & Statistics, Growth Forecasts (2025 - 2030)
Market Report I 2025-04-28 I 129 Pages I Mordor Intelligence
The Unresectable Hepatocellular Carcinoma Market size is estimated at USD 2.19 billion in 2025, and is expected to reach USD 3.34 billion by 2030, at a CAGR of 8.84% during the forecast period (2025-2030).
The COVID-19 pandemic has significantly impacted the unresectable hepatocellular carcinoma market. As per a research study titled "Impacts of COVID-19 on Liver Cancers: During and after the Pandemic", published in the National Library of Medicine in May 2020, hepatocellular carcinoma (HCC) patients are more vulnerable to the effects of COVID-19 than other cancer patients as the hepatic injury caused by SARS-CoV-2 could complicate the existing hepatitis virus infection and cirrhosis. Further, barriers to accessing cancer drugs during the COVID-19 pandemic endangered the stability and integrity of pharmaceutical supply chains, thus limiting the supply of drugs across healthcare facilities. Thus, the COVID-19 pandemic has altered healthcare priorities, which may adversely impact HCC management.
The major factors fueling the market's growth are the high incidence rate of liver carcinoma and the advancement in new treatment options.
The high incidence rate of liver carcinoma is a major factor driving the market's growth. According to a September 2021 update by the Centers for Disease Control and Prevention, each year, about 24,500 men and 10,000 women in the United States get liver cancer, and about 18,600 men and 9,000 women die from the disease. As per the statistics, there is a significant rise in the patient pool, which is expected to boost the market's growth. Additionally, according to GLOBOCAN 2020, the estimated number of new liver cancer cases worldwide in 2020 was 906,000, and the number is expected to reach 1.40 million by 2040. Thus, the increasing incidence rate of liver cancer reflects the growing rate of unresectable hepatocellular carcinoma, which is augmenting the demand for unresectable HCC treatment.
Moreover, advancements in new treatment options are boosting the market's growth. For instance, according to an article published in Karger Journal, in 2021, various phase 3 trials reported a clinical benefit for the tyrosine kinase inhibitors lenvatinib, regorafenib, and cabozantinib in HCC. Additionally, as per a 2022 update by The Reagents of the University of California, 51 clinical trials are in progress for hepatocellular carcinoma treatment. As per an October 2021 published article titled "Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Hepatocellular Carcinoma: A New Update", hepatic arterial infusion chemotherapy (HAIC) has greater survival in patients with advanced HCC. Thus, the availability of advanced drugs in the treatment of hepatocellular carcinoma is expected to boost the market over the forecast period.
However, fewer diagnoses and poor efficacy of current therapeutic agents are major factors restraining the market's growth.
Unresectable Hepatocellular Carcinoma Market Trends
Chemotherapy Holds Significant Share in the Unresectable Hepatocellular Carcinoma Market
By treatment, the chemotherapy segment is expected to witness significant growth. The major factors fueling the segment's growth are the increasing prevalence of hepatocellular carcinoma, the growing number of drug approvals, and advancements in new treatment options.
For instance, as per a 2021 update by the American Society of Clinical Oncology (ASCO), chemoembolization is a type of chemotherapy treatment similar to hepatic arterial infusion. The same source also reported that drugs are injected into the hepatic artery during this procedure, and the flow of blood through the artery is blocked for a short time. Thus, the chemotherapy stays in the tumor for a longer period, making chemotherapy treatment more effective. Therefore, such factors are boosting the adoption of chemotherapy as a better treatment option for patients suffering from HCC, thereby contributing to the segment's growth.
Furthermore, a news article published in February 2022 detailed a study conducted at Tianjin Cancer Hospital in China. The researchers examined 35 patients with intermediate/advanced HCC at Tianjin Cancer Hospital. The study concluded that in patients with unresectable hepatocellular carcinoma (HCC), the most frequent kind of primary liver cancer, combining PD-1 immune checkpoint suppression with transarterial chemotherapy and Lenvima (lenvatinib) improved prognosis. Such factors increase the adoption of chemotherapy among the patient population, thus driving the segment's growth.
Thus, the factors mentioned above are anticipated to boost the segment's growth over the forecast period.
North America Dominates the Unresectable Hepatocellular Carcinoma Market
Within North America, the United States holds the major share of the market. Factors such as the increasing prevalence of liver cancer in the country, technological advancements in drug development, increasing R&D investments, and the growing geriatric population are expected to drive the US unresectable hepatocellular carcinoma market during the forecast period. According to data by GLOBOCAN 2020, the estimated number of liver and intrahepatic bile duct cancer cases in the country was 42,284 in 2020. The number is expected to reach 52,703 by 2040. Unresectable hepatocellular carcinoma is the most common type of liver cancer. The expected increase in cancer cases in the country may drive the market's growth.
Several market players are engaged in implementing strategic initiatives, thereby contributing to the market's growth. For instance, in February 2022, Eureka Therapeutics Inc., a clinical-stage biotechnology company developing novel T-cell therapies to treat solid tumors, reported that the US Food and Drug Administration (FDA) granted Orphan Drug Designation (ODD) to ET140203 and ECT204 for the treatment of hepatocellular carcinoma (HCC), the most common form of liver cancer. In January 2020, AstraZeneca's durvalumab (Imfinzi) and tremelimumab were granted the US FDA Orphan Drug Designation to treat hepatocellular carcinoma (HCC).
Thus, due to the above-mentioned factors, the market is expected to grow significantly in the region over the forecast period.
Unresectable Hepatocellular Carcinoma Industry Overview
The unresectable hepatocellular carcinoma market is moderately competitive and consists of a few major players. Companies like AstraZeneca PLC, Bayer AG, Bristol-Myers Squibb Company, Celgene Corporation, Eisai Co. Ltd, F. Hoffmann-La Roche Ltd, Merck & Co. Inc., and Pfizer Inc. hold a substantial market share.
Additional Benefits:
- The market estimate (ME) sheet in Excel format
- 3 months of analyst support
1 INTRODUCTION
1.1 Study Deliverables
1.2 Study Assumptions
1.3 Scope of the Study
2 RESEARCH METHODOLOGY
3 EXECUTIVE SUMMARY
4 MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 High Incidence Rate of Liver Carcinoma
4.2.2 Advancement in New Treatment Options
4.3 Market Restraints
4.3.1 Less Diagnosis and Poor Efficacy of Current Therapeutic Agents
4.4 Porter's Five Forces Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5 MARKET SEGMENTATION (Market Size by Value - USD million)
5.1 By Treatment
5.1.1 Chemotherapy
5.1.2 Molecularly Targeted Therapy
5.1.3 Immunotherapy
5.1.4 Other Treatments
5.2 By End User
5.2.1 Hospitals
5.2.2 Cancer Centers
5.2.3 Other End Users
5.3 By Geography
5.3.1 North America
5.3.1.1 United States
5.3.1.2 Canada
5.3.1.3 Mexico
5.3.2 Europe
5.3.2.1 Germany
5.3.2.2 United Kingdom
5.3.2.3 France
5.3.2.4 Italy
5.3.2.5 Spain
5.3.2.6 Rest of Europe
5.3.3 Asia-Pacific
5.3.3.1 China
5.3.3.2 Japan
5.3.3.3 India
5.3.3.4 Australia
5.3.3.5 South Korea
5.3.3.6 Rest of Asia-Pacific
5.3.4 Middle-East and Africa
5.3.4.1 GCC
5.3.4.2 South Africa
5.3.4.3 Rest of Middle-East and Africa
5.3.5 South America
5.3.5.1 Brazil
5.3.5.2 Argentina
5.3.5.3 Rest of South America
6 COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Astrazeneca PLC
6.1.2 Bayer AG
6.1.3 Bristol-Myers-Squibb Company
6.1.4 Celgene Corporation
6.1.5 Eisai Co. Ltd
6.1.6 F. Hoffmann-La Roche Ltd
6.1.7 Merck & Co. Inc.
6.1.8 Pfizer Inc.
6.1.9 Chugai Pharmaceutical Co. Ltd
6.1.10 Pharmaxis
6.1.11 Eli Lilly
6.1.12 BeiGene
7 MARKET OPPORTUNITIES AND FUTURE TRENDS
- Not Sure / Need Reassuring
- Confirm Content
-
Content is provided by our partners and every effort is made to make Market Report details as clear as possible. If you are not sure the exact content you require is included in this study you can Contact us to double check. To do this you can:
Use the ‘? ASK A QUESTION’ below the license / prices and to the right of this box. This will come directly to our team who will work on dealing with your request as soon as possible.
Write to directly on support@scotts-international.com with details. Please include as much information as possible including the name of report or link so our staff will be able to work on you request.
Telephone us directly on 0048 603 394 346 and an experienced member of team will be on hand to answer.
-
- Sample Pages
-
With the vast majority of our partners we can obtain Sample Pages to support your decision. This is something we can arrange without revealing your personal details.
It is important to note that we will not be able to provide you the exact data or statistics such as Market Size and Forecasts. Sample pages usually confirm the layout or the Categories included in Charts and Graphs, excluding specific data.
To ask for Sample Pages by contact us through ‘? ASK A QUESTION’, support@scotts-international.com, or by telephoning 0048 603 394 346.
-
- Check for Alternatives
-
Whilst we try to make our online platform as easy to use as possible there is always the possibility that a better alternative has not been found in your search.
To avoid this possibility Contact us through ‘? ASK A QUESTION’, support@scotts-international.com, or by telephoning 0048 603 394 346 and a Senior Team Member can review your requirements and send a list of possibilities with opinions and recommendations.
-
- Confirm Content
- Prices / Formats / Delivery
- Prices
-
All prices are set by our partners and should be exactly the same as those listed on their own websites. We work on a Revenue share basis ensuring that you never pay more than what is offered elsewhere.
Should you find the price cheaper on another platform we recommend you to Contact us as we should be able to match this price. You can Contact us though through ‘? ASK A QUESTION’, support@scotts-international.com, or by telephoning 0048 603 394 346.
-
- Discounts
-
As we work in close partnership with our Partners from time to time we can secure discounts and assist with negotiations, this is part of our personalised service to you.
Discounts can sometimes be arranged for speedily placed orders; multiple report purchases or Higher License purchases.
To check if a Discount is possible please Contact our experienced team through ‘? ASK A QUESTION’, support@scotts-international.com, or by telephoning 0048 603 394 346.
-
- Available Currencies
-
Most Market Reports on our platform are listed in USD or EURO based on the wishes of our Partners. To avoid currency fluctuations and potential price differentiations we do not offer the possibility to change the currency online.
Should you wish to pay in a different currency to that advertised online we do accept payments in USD, EURO, GBP and PLN. The price will be calculated based on the relevant exchange rate taken from our National Bank.
To pay in a different above currency to that advertised online please Contact our team and a quotation will be sent within a couple of hours with payment details.
-
- Licenses
-
License options vary from Partner to Partner as is usually based on the number of Users that will benefitting from the report. It is very important that License ordered is not breached as this could have potential negative consequences for you individually or your employer.
If you have questions or need confirmation about the specific license we recommend you to Contact us and a detailed explanation will be provided.
-
- Global Site License
-
The Global Site License is the most comprehensive license available. By selecting this license, the Market Report can be shared with other ‘Allowed Users’ and any other member of staff from the same organisation regardless of geographic location.
It is important to note that this may exclude Parent Companies or Subsidiaries.
If you have questions or need confirmation about the specific license we recommend you to Contact us and a detailed explanation will be provided.
-
- Formats
-
The most common format is PDF, however in certain circumstances data may be present in Excel format or Online, especially in the case of Database or Directories. In addition, for certain higher license options a CD may also be provided.
If you have questions or need clarification about the specific formats we recommend you to Contact us and a detailed explanation will be provided.
-
- Delivery
-
Delivery is fulfilled by our partners directly. Once an order has been placed we inform the partner by sharing the delivery email details given in the order process.
Delivery is usually made within 24 hours of an order being placed, however it may take longer should your order be placed prior to the weekend or if otherwise specified on the Market Report details page. Additionally, if details have been not fully completed in the Order process a delay in delivery is possible.
If a delay in delivery is expected you will be informed about it immediately.
-
- Shipping Charges
-
As most Market Reports are delivered in PDF format we almost never have to add additional Shipping Charges. If, however you are ordering a Higher License service or a specific delivery format (e.g. CD version) charges may apply.
If you are concerned about additional Shipping Charges we recommend you to Contact us to double check.
-
- Prices
- Ordering
- By Credit Card
-
We work in Partnership with PayU to ensure payments are made securely in a fast and effortless way. PayU is the e-payments division of Naspers.
Naspers operates in over 133 International Markets and ranks 3rd Globally in terms of the number of e-commerce customers served.
For more information on PayU please visit: https://www.payu.pl/en/about-us
-
- By Money Transfer
-
If you require an invoice prior to payment, this is possible. To ensure a speedy delivery of the Market Report we require all relevant company details and you agree to maximum payment terms of 30 days from receipt of order.
With our regular clients deliver of the Market Report can be made prior to receiving payment, however in some circumstances we may ask for payment to be received before arranging for the Market Report to be delivered.
-
- By Credit Card
- Security
- Website security
-
We have specifically partnered with leading International companies to protect your privacy by using different technologies and processes to ensure security.
Everything submitted to Scotts International is encrypted via SSL (Secure Socket Layer) and all personal information provided to Scotts International is stored on computer systems with limited access in controlled environments.
-
- Credit Card Security
-
We partner with PayU (https://www.payu.pl/en/about-us) to ensure all credit card payments are made securely in a fast and effortless way.
PayU offers 250+ various payment channels and eWallet services across 4 continents allowing buyers to pay electronically, whether on a computer or a mobile device.
-
- Website security